A facile and practical p-toluenesulfonic acid catalyzed route to dicoumarols and their biological evaluation

New Dicoumarols 2a-g efficiently synthesized employing p-TSA as a catalyst from the reaction of 4-hydroxycoumarin with aryl aldehydes in water. This method offers direct access to structurally diverse derivatives good yields (65-94%). Upon heating 3,3' -arylidenebis-4-hydroxycoumarins derivative acetic anhydride, epoxydicoumarins were formed. 1H, 13C{1H}-NMR, elemental analysis, and infrared spectroscopic techniques used for characterization obtained compounds. A possible relationship between such hydrogen-bonded structures antimicrobial antioxidant activities compounds is suggested. The synthetized 3a-g subjected vitro antifungal against DNA gyrase Mycobacterium tuberculosis-CYP51 target proteins at active sites. Compound 3d shows effective inhibitory effect terms MIC = 15 µg mL-1. Salmonella typhimuriumATCC 14028. Compounds 2b, 2c, 3b, 3c, 3e 3g have recorded an important scavenging activity radical DPPH. EC50 these was 47.17, 46.90, 50.55,48.27 , 46.55 47.54 mL-1 respectively. Investigation anti-inflammatory showed that 2b,2c, 3f, 3b 3c are most potent inflammatory activities.